Prof. Dr. rer. Nat. Hesham A. El Enshasy
School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM)
Title: Bioprocess platform design for large scale production of bioactive molecules from Mushrooms
Abstract: For centuries, mushrooms have been widely used as food and medicine in different ancient cultures especially in Asia and Mediterranean regions. Recently, many bioactive compounds have been isolated and identified from different mushrooms. These biomolecules showed medicinal values with high potential application for the treatment of many diseases. Of these compounds, immunomodulators and anticancers gained more interest due to the increased demand of new, effective, and safe drug to enhance immune system and act against cancer cells. In general, these compounds were classified under four main categories based on chemical structure as: Proteins, Lectins, Terpenoids, and polysaccharies. in addition to some new low molecular weight compounds. However, for many years mushrooms cultivation was mainly carried out in green house with many disadvantages in terms of long time cultivation, ease of contamination, and low production of the targeted compounds. For the production of bioactive molecules under fully sterile conditions at high concentration, submerged cultivation system was proven as alternative for large scale production to cover the increased market demand. In addition, this process decrease the production time, increase the yield of the targeted molecules, and also reduce many steps in downstream processes. This talk will provide a comprehensive information on production of bioactive molecules in different submerged cultivation systems by providing examples for the large scale production of mushrooms immunomodulator compounds for medical and nutraceutical industries.
Prof. Hesham Ali El Enshasy is Director of Institute of Bioproduct Development (IBD), and professor in bioprocess engineering, school of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM). Chair for Food Division 15A (2016-2017) AIChE, and the current co-Chair for Food, Pharmaceutical& Bio-Engineering Division, Division 15A (Food), American Institute of Chemical Engineering (AIChE).
Before joining UTM, he was the assistant director of City for Scientific Research for Research Institutes Affairs (Alexandria, Egypt). Prof. El Enshasy received his B.Sc. and M.Sc. in Microbiology (Ain Shams University, Egypt), Dr. rer. Nat. in Industrial Biotechnology (TU Braunschweig, Germany 1998), M.Sc. Technology Management (UTM, Malaysia). Post Doc. Faculty of Chemical Engineering, The Ohio State Univ. (USA) and GBF, (Germany). He is also visiting guest professor and honor guest professor to many world class universities in USA, Germany, China, Sweden, Japan, Australia, Saudi Arabia, Greece, and Algeria.
He established many research and industrial platforms for the industrial production of different bioactive metabolites using microbial, mammalian and plant cells in many universities, research institutes and companies. Prof. El Enshasy is active as editorial board member in many scientific journal and he is currently the Editor-in-Chief for International Journal of Biotechnology for Wellness Industries (IJBWI) and Bioscience Biotechnology Research Asia (BBRA). He is also the current editor of book series Industrial Biotechnology (CRC Press, USA).
Prof. El Enshasy has two technology patents and more than 150 publications in peer reviewed international journals, book Chapters, and books. He was also invited as keynote, plenary, and guest speaker in more than 60 international conferences in field of industrial biotechnology. He is also active as advisory board member, scientific and bio-business consultant for biotechnology companies in Egypt, Belgium, Greece, USA, China and Malaysia for the important three Ts (Technology Transfer, Technology Implementation and Technology Development) as well as process and platform designer for chemical processing and Biotechnology industries.